Later data on effectiveness (the vaccine's performance when used in the real world) for adults showed that the protection from the mRNA two-dose primary series wanes over time; but booster doses bring the immune system back to robust levels. So Novavax is a far better buy than Pfizer, in addition to having the best Covid vaccine in most areas. Transitioningfrom medical student to resident can be a challenge. Knowing those differences may be a deciding factor for hesitant individuals. The main difference between the Novavax vaccine and the already-approved and widely used vaccines from Pfizer/BioNTech and Moderna is the technology behind the shots. Our New COVID-19 VocabularyWhat Does It All Mean? How is Novavax different from the other COVID vaccines? Novavax is slightly different, the first one is the vaccine, and the second one is a Matrix-M adjuvant, which it's not the vaccine, it just increases your immunity. A Novavax Booster Is Here. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. The AMA provides regulatory clarification to physicians and their care teams in an effort to aid physicians in their day-to-day practice environment. How it works: Unlike the mRNA and vector vaccines, this is a protein adjuvant (an adjuvant is an ingredient used to strengthen the immune response). SINGAPORE The incidence rate of suspected cases of adverse reactions from Novavax COVID-19 vaccine doses given in Singapore is higher than those of the other three vaccines under the national vaccination programme, according to a Health Sciences Authority (HSA) report.. All four were not serious and had reported experiencing rash, There was no comparative data for the CoronaVac vaccine in the latest HSA report, its 12th on the roll-out of COVID-19 vaccines in Singapore. Immunocompromised teenagers and adults ages 12 and older can receive a 2nd booster (4th dose) of an mRNA vaccine at least four months after their first booster. Is This the Telltale Sign to Sell Novavax Stock? [Originally published: July 20, 2022. It contains the spike protein of the coronavirus itself, but formulated as a nanoparticle, which cannot cause disease. After vaccination, your muscle cells begin making the S protein pieces and displaying them on cell surfaces. Possible side effects:Pain, redness, or swelling at the site where the shot was administered, and/or tiredness, headache, muscle pain, chills, fever, or nausea throughout the rest of the body. We know that the risk of heart complications is higher after COVID disease than after mRNA COVID vaccination among males and females of all ages. Information provided in Yale Medicine articles is for general informational purposes only. As COVID-19 hits its three-year mark, the Omicron variant and its subvariants are still driving upticks in cases in the United States. This will take much less time with mRNA vaccines since once the genomic target is identified, mRNA signature can be quickly and easily edited, and a new version of the vaccine can be manufactured. And, unlike mRNA vaccines, protein-based vaccines do not contain any genetic material, said Dr. Fryhofer. The company plans to file for U.S. Food and Drug Administration (FDA) approval. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Notably there were few infections among people in the study who were Hispanic or Latino overall (just 8 in the Novavax group and 11 in the placebo group), making these results somewhat difficult to interpret. Novavax says it expects to have an updated shot in 2023 but says its booster does provide protection against several strains, including BA.5. Anyone 12 or older can get the Novavax vaccine. FDA warnings:The FDA placed awarning labelon the Moderna vaccine regarding a likely association with reported cases of heart inflammation in young adults. Another study in January from the CDC assessed the bivalent vaccines effectiveness against the most recent Omicron subvariants, XBB and XBB.1.5, in people who had previously received two to four monovalent vaccine doses, and found it to be similar to how well it worked against BA.5 for at least the first three months after vaccination. No, Novavax does not use mRNA. FDA Is Considering Annual COVID Vaccines. A few side effects are serious, but rare. But 21 cases of appendicitis inflammation of the appendix have been reported among the over 11 million Pfizer doses administered here, HSA added. While the mRNA bivalent boosters from Pfizer and Moderna target both the original strain of the coronavirus and Omicron BA.4 and BA.5 subvariants, the Novavax booster only targets the original SARS-CoV-2 virus. How well it works on virus variants: The data presented to the FDA was gathered before Omicron or its recent subvariants started to circulate, but the company says it expects to have a vaccine that will protect against the recent Omicron subvariants in 2023. Myocarditis, a rare form of inflammation of the heart muscle, occurred in a handful of Novavax clinical trial participants, all of whom were men. Access reports from the Council on Medical Education presented during the AMA Annual and Interim Meetings. Taylor Carmichael owns shares of Novavax. Novavaxs vaccine has gained a cult following on social media sites like Reddit and Twitter because it uses protein-based technology rather than the relatively new mRNA technology, Fortune reported. We now have a third type of vaccine in the fight against COVID, Dr. Fryhofer said during an episode of the AMA COVID-19 Update about the Novavax vaccine. The biggest difference is the way the vaccine works. People have been talking, should we just do one vaccine and skip the second one. Whereas Novavax is going be simpler. were also circulating, which suggests the updated vaccine is more effective against those strains in addition to the ones it was designed to target. Adults with certain immune deficiencies should also get a second Pfizer-BioNTech or Moderna booster; immunocompromised teenagers ages 12-17 must get this booster from Pfizer. Johnson & Johnson and Novavax are approaching the finish line in this race. Children who have had all three Pfizer primary shots already are not eligible at this time for the updated booster.) Novavax may ultimately produce more vaccines and there's also distribution differences too, because Moderna's and Pfizer's has to be frozen or kept really cold. But experts have pointed to an additional interesting tidbit in the research: This new vaccine may cause fewer side effects than those currently available in the U.S. Find savings to help organize personal finances and manage debt. They all have 100% efficacy for severe COVID-19 disease.. In December, the FDA updated its fact sheet on the shot to include information about the rare but serious blood clotting disorder called thrombosis with thrombocytopenia syndrome (TTS) that was associated with the vaccine. Novavax's vaccine uses a traditional mechanism as compared to mRNA vaccines. So Novavax is a far better buy than Pfizer, in addition to having the best Covid vaccine in most areas. But experts have pointed to an additional interesting tidbit in the research: This new vaccine may cause fewer side effects than those currently available in the U.S. Based on their data, the Novavax vaccine has a significantly lower rate of side effects compared to the Pfizer-BioNTech and Moderna vaccines. FDA warnings: The FDA added a warning label on the mRNA vaccines regarding serious (but rare) cases of inflammation of the heart muscle (myocarditis) and of the outer lining of the heart (pericarditis) in adolescents and young adults, more often occurring after the second dose of an mRNA vaccine. Novavax applied to the FDA for authorization in January of this year. Novavax is a different type of COVID-19 vaccine than what has been previously approved or authorized in the U.S. The mRNA vaccines, like Pfizer and Moderna , contain a piece of genetic code called RNA that the body creates an immune response for. The Novavax booster targets the original SARS CoV-2 virus and may not protect against infection by Omicrons recent subvariants. Both Pfizers and Modernas vaccines use messenger RNA (mRNA) to deliver a blueprint of sorts to cells in the body. Thats what it is, Dr. Wilson says. In accordance with the WHO Prioritization Roadmap, More information for immunocompromised people is available on theCDC website. Stay in the know on-the-go: Join Yahoo Singapore's Telegram channel at http://t.me/YahooSingapore, its 12th on the roll-out of COVID-19 vaccines in Singapore, Lori Lightfoot becomes the first Chicago mayor in 40 years to lose re-election, Fiery Greece train collision kills 32, injures at least 85, A condition called POTS rose after covid, but patients can't find care, Drones fly deep inside Russia; Putin orders border tightened, Rep. Lauren Boebert Gets Absolutely Schooled By Jamie Raskin Using Trump's Own Words, SoCal storm timeline: More snow, heavier rain expected Wednesday, The Ultimate Online People Finder: Discover TruePeopleSearchs Advanced People Search Capabilities, Government must build a better process for infrastructure projects | Opinion. Robert Malone promoted it as better than the mRNA vaccines. The Novavax COVID-19 vaccine was recently granted emergency use approval by the FDA. Not as quick. You're still going to see transmission of COVID, even among vaccinated people, Dr. Wilson says. So Novavax is a far better buy than Pfizer, in addition to having the best Covid vaccine in most areas. It uses the spike proteins themselves, in the form of nanoparticles, to trigger an immune response. After a second dose of the Pfizer vaccine : 66% reported pain Because information about COVID-19 changes rapidly, we encourage you to visit the websites of the Centers for Disease Control & Prevention (CDC), World Health Organization (WHO), and your state and local government. Who can get it: Adults 18 and older who specifically request the J&J vaccine or who cannot have the other available vaccines for medical reasons. Novavax is trailing by about six months. The Novavax vaccine is the fourth one to beauthorized in the United Statesfor the prevention of COVID-19. MSOP outreach leaders: Find ready-to-post content, graphics and logos here. Early last month, the pharmaceutical company Novavax shared that its two-dose COVID-19 vaccine was more than 90% effective at preventing COVID-19. Later data on real-world effectiveness for adults showed that the protection from the mRNA two-dose primary series wanes over time, but booster doses bring the immune system back to robust levels. I often tell people, imagine an eggshell without an egg in it. The Novavax clinical trial was conducted before the Omicron variant was circulating, so data doesnt show how well the vaccine works against recent subvariants. Rare cases of appendicitis have been reported following vaccination with COVID-19 vaccines globally. The mRNA COVID-19 vaccines dont use a weakened or inactivated virus to trigger an immune response either. It must be stored in freezer-level temperatures, which can make it more difficult to distribute than some other vaccines. How well it works: Modernas initial Phase 3 clinical data in December 2020 was similar to Pfizer-BioNTechsat that point, both vaccines showed about 95% efficacy for prevention of COVID-19. Information provided in Yale Medicine articles is for general informational purposes only. Subunit vaccines are reliable and familiarthey have been around for many years. Infants as young as 6 months, children, and teenagers are also eligible for the Pfizer bivalent booster. The tangled history of mRNA vaccines. There's some data suggesting that certain proteins in the heart look like spike proteinsbut it doesn't look that much like a spike protein, so why certain individuals have more of a reaction than others is still not clear, says Dr. Wilson. Messenger RNA (mRNA) vaccine. It uses a different technology. With expert resources and tireless advocacy, the AMA is your powerful ally against COVID-19. Dosages for children are different than dosages for adults. Will Novavax have a longer shelf life in the immune system? Novavax is a different type of COVID-19 vaccine than what has been previously approved or authorized in the U.S. I think Pfizer's manufacturing all their stuff in-house, and Moderna, I believe, is farming it out to other people, but it's very complicated. KFF COVID-19 vaccine monitor - April 2021. Globally, we continue to learn about new variants of the COVID-19 virus, and we are still learning more about long-term vaccine effectiveness over time. No, Novavax does not use mRNA. COVID-19 infection is also known to be associated with myocarditis, with 40 extra myocarditis events per million persons observed among those infected with the virus based on published data, according to HSA. Its important to note that, for both age groups, the data on the vaccines efficacy was gathered before Omicron became the predominant variant, so its efficacy against Omicron and its subvariants is unknown. I think they're going to reach a higher number of doses ultimately, they think 2 billion. Adults who are immunocompromised can choose between the three available vaccines, following a schedule similar to immunocompromised teens (depending on which vaccine they choosePfizer or Moderna are recommended over Johnson & Johnson). The AMA Update covers a range of health care topics affecting the lives of physicians and patients. However, we can't directly compare myocarditis rates between Novavax and mRNA vaccines based on currently available data, Dr. Fryhofer added. Robert Malone promoted it as better than the mRNA vaccines. (Antibodies are known to provide protection against infection or reinfection and severe disease.) The FDA granted the Moderna vaccine (brand name: Spikevax) full approval for people 18 and older in January 2022, upgrading the vaccines EUA, which was granted in December 2020 (a week after Pfizer-BioNTech). We did -- go ahead. It uses the spike proteins themselves so our body can recognize and fight the virus when we are exposed to it in the future. The Novavax coronavirus vaccine (brand names:Nuvaxovid andCovovax) is already being used to prevent the coronavirus in 40 other countries, including Canada. If any of these side effects occur, they should go away in a few days. Now, in the Novavax clinical safety study, there were only four to six cases identified out of more than 40,000 vaccine recipients. The FDA authorized Johnson & Johnsons coronavirus vaccine (brand name: Janssen) in February 2021. We know how supply chains can get disrupted, and we want to make sure there's adequate vaccine available. It uses the spike proteins themselves, in the form of nanoparticles, to trigger an immune response. 1. With the approval of Novavax, healthcare providers and individuals would have more options to choose from, which may increase national and global demand. No increased incidence of appendicitis has been observed with the booster dose of the vaccine, according to HSA. This extended interval recommendation does not apply to those with immunocompromised conditions, Dr. Fryhofer added. Messenger RNA (mRNA) vaccine. Navigating the COVID-19 Pandemic With Rheumatoid Arthritis. After all, the newsletter they have run for over a decade, Motley Fool Stock Advisor, has tripled the market.*. Because of our current system of employer-based health insurance in the U.S., concerns about job security may also lead to concerns about disruptions in access to healthcare, in the event of job loss.. According to recent Census Bureau data, more than half of unvaccinated Americans live in households that make less than $50,000 annually. An 8-week interval is recommended between primary series doses of NVX-CoV2373. Peter McCullough said it would be a safer vaccine . You get the first one and then get the second one, it's definitely worth your time and they're free. iPhone or It's fine to give flu shots and COVID vaccines at the same time, and that also goes for the Novavax vaccine. We regret the error. I verify that Im in the U.S. and agree to receive communication from the AMA or third parties on behalf of AMA. Can People With MS Get the COVID-19 Vaccine? Founded in 1993 by brothers Tom and David Gardner, The Motley Fool helps millions of people attain financial freedom through our website, podcasts, books, newspaper column, radio show, and premium investing services. Is it one or two doses? The Novavax vaccine was approved for use in Canada on Feb. 17, adding yet another Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. The availability of the Novavax COVID-19 vaccine offers another option for people who may have been hesitant about getting vaccinated. For some people older than 12, especially boys and men between ages 12 and 39, the CDC suggests an eight-week interval between the two shots to reduce the risk of myocarditis, an uncommon side effect (see FDA warnings below). After a second dose of the Pfizer vaccine : 66% reported pain There's some data suggesting that certain proteins in the heart look like spike proteinsbut it doesn't look that much like a spike protein, so why certain individuals have more of a reaction than others is still not clear, says Dr. Wilson. However, we can't directly compare myocarditis rates between Novavax and mRNA vaccines based on currently available data, Dr. Fryhofer added. If you haven't been vaccinated yet and you're concerned about losing a day's worth of pay, it's best to check with your employer. This causes your body to create Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services. Officials and members gather to elect officers and address policy at the 2023 AMA Annual Meeting being held in Chicago, June 9-14, 2023. Is Novavax Stock a Buy With the New Normal for COVID? Some studies of mRNA vaccines have indicated a lower risk of myocarditis and greater immune response with that extended interval, she said. Novavaxs vaccine has gained a cult following on social media sites like Reddit and Twitter because it uses protein-based technology rather than the relatively new mRNA technology, Fortune reported. The efficacy of Novavax against virus variants is unknown at this time. 2 FAANG Stocks Billionaires Are Selling in Droves and 1 They Can't Stop Buying, 2 Growth Stocks That Can Turn $250,000 Into $1 Million by 2030, 1 Bargain-Basement Warren Buffett Stock Down 78% to Buy Before It Starts Soaring, Billionaire Investor Bill Ackman Is Raking In $97 Million In Annual Dividend Income From These 2 Stocks, Join Over Half a Million Premium Members And Get More In-Depth Stock Guidance and Research, Copyright, Trademark and Patent Information. Who can get it:Infants, children, and adults ages 6 months and older in the U.S. There is that differences and that's (an) important difference from the point of view of speed. An adverse event is classified as serious when it results in hospitalisation, a significant reduction in functioning level, a life-threatening illness, or death. Determining the best antigen to include in the vaccine takes time and it will take longer to change this antigen if needed, Yildirim says. Explore how to write a medical CV, negotiate employment contracts and more. Novavax is not necessarily more effective or reliable than mRNA vaccines. If you had COVID-19 recently, you might consider delaying your second primary dose or your booster by 3 months from when you started to experience symptoms or (if you had no symptoms) the date of your positive test result. A one-shot strategy made J&Js vaccine easier to distribute and administer to people who found it the be the most convenient vaccine to get. And remember, Novavax and other COVID vaccines are reactogenic and can have significant side effects, she said. If you had COVID-19 recently, you might consider delaying your second primary dose or your booster by 3 months from when you started to experience symptoms or (if you had no symptoms) the date of your first positive test result. Dosage:Single shot. Finally, in November 2021, countries around the world, starting with Indonesia and the Philippines, later followed by the United Kingdom, began granting authorizations for the vaccine. One is that this is an additional vaccine choice that may be acceptable to some of the more than 30% of Americans who are not fully vaccinated, he explains. These side effects usually go away within one to two days.. Not every residency match is made to last, as more than 1,000 residents transfer programs each year. In November 2022, Pfizer announced that a clinical trial showed levels of neutralizing antibodies in the bivalent booster were fourfold higher in people 55 and older than in people of similar ages who got a monovalent booster, which targeted only the original virus. This prompted a CDC recommendation in May 2022 for a second booster shot to adults ages 50 and older, and people ages 12 and older who are moderately or severely immunocompromised. In May, the FDA put new restrictions on who can get the J&J vaccine based on another review of data on the life-threatening clots. Of these events, 24 were serious. An 8-week interval is recommended between primary series doses of NVX-CoV2373. It's different than the mRNA vaccines, it's more old school, I'm going to mispronounce this word, a recombinant. Who can get it:Anyone ages 16 and older in the U.S. This technology is behind many of the routine childhood vaccinations for whooping cough, diphtheria, tetanus, and hepatitis B. If we need additional booster shots in the future, it will be important for us to have an appropriate vaccine supply here in the U.S.. Bivalent booster shots authorized in August 2022 are designed to protect against disease caused by the original strain of the SARS-CoV-2 virus, as well as Omicron variants BA.4 and BA.5. All rights reserved. Dosage: 2 doses, 3-8 weeks apart. Our New COVID-19 VocabularyWhat Does It All Mean. Though COVID vaccines may utilize different delivery mechanisms, the end result is the same: cells in the body recognize that a spike protein (the spikes you see sticking out of the coronavirus in pictures) doesnt belong, and the immune system reacts by activating immune cells and producing antibodies to attack the real virus if you get exposed. The company also announced that it started a study in May looking at Novavax boosters after an mRNA primary vaccine series, Dr. Fryhofer explained. There is a huge experience behind this technology, Yildirim says. By Carla Delgado Carla M. Delgado is a health and culture writer based in the Philippines. With the mRNA vaccines, the inflammation, in most cases, gets better on its own without treatment. SINGAPORE The incidence rate of suspected cases of adverse reactions from Novavax COVID-19 vaccine doses given in Singapore is higher than those of the other three vaccines under the national vaccination programme, according to a Health Sciences Authority (HSA) report.. All four were not serious and had reported experiencing rash, The Novavax Covid-19 vaccine, which goes by the Scrabble-friendly trade name Nuvaxovid, has been authorized as a two-dose primary series given three weeks. The symptoms commonly reported were similar to those already associated with COVID-19 vaccines like fatigue, headache, and muscle pain. In August, authorization for the vaccine was expanded to include adolescents ages 12 to 17, based on data from Novavaxs ongoing pediatric trial. SAGE recommends the use of the Novavax (NVX-CoV2373) vaccine as 2 doses (0.5 ml) given intramuscularly. Moderna(MRNA 0.39%) andPfizer(PFE -0.52%) have seized an early lead in vaccine distribution in the United States. The subunits included in the vaccine are necessary to elicit a protective immune response, but they are not live, or they are not whole viruses and cannot cause disease in the vaccine recipient.. Kaiser Family Foundation. Download AMA Connect app for But the possibility for fewer side effects and the use of reliable, trusted vaccine technology may work to convince those who remain unvaccinated to get their shot. Vaccine efficacy in this older group was 79%. A few side effects are serious, but rare. Carmichael: Nanoparticle. Dosages for infants and children are different than those for adults. But if you want it to work, I would get both shots. Also, there's no problem giving Novavax or any of the other COVID vaccines with other vaccines with one exception: orthopoxvirus vaccines, she added, noting that while we're in the middle of a monkeypox outbreak ACAM2000 and JYNNEOS are the two vaccines available for orthopoxvirus viruses.. As at 31 May, four cases of adverse reactions were reported out of the 2,792 doses of Nuvaxovid administered here, at a 0.14 per cent incidence rate, the report published on Monday (27 June) shows. Copyright 1995 - 2023 American Medical Association. Dr. Fryhofer also serves as the AMAs liaison to the Centers for Disease Control and Preventions (CDC) Advisory Committee on Immunization Practices (ACIP) and is a member of ACIPs COVID-19 Vaccine Work Group. The efficacy of Novavax against virus variants is unknown at this time. The first and second doses of the Novavax COVID-19 vaccine are identical, and not different as the author states below. The AMA is fighting to permanently remove restrictions on telehealth coverage and payment. 10 stocks we like better than Novavax When our award-winning analyst team has a stock tip, it can pay to listen. United States Census Bureau. Novavax says there is insufficient evidence to establish a causal relationship" between the vaccine and the condition. The CDCs study was based on COVID-19 tests performed in the pharmacy, and it found effectiveness against the XBB strains varied by age: in ages 18 to 49, it was 49% against the XBB strains versus 52% against the BA.5 viruses; in ages 50 to 64, it was 40% compared to 43% for BA.5; and in people 65 and older, 43%, compared to 37% for the BA.5 viruses. The Omicron surge started in December 2021 and still dominates. It uses the spike proteins themselves so our body can recognize and fight the virus when we are exposed to it in the future. How well it works against variants: While Pfizers primary vaccine was designed to protect against the original SARS CoV-2 virus, the new bivalent (or updated) booster is designed to prevent two virus strains, the original one and the Omicron subvariants BA.4 and BA.5. The HOD speakers welcome comments for reports under development for the upcoming Interim and Annual Meetings. Moderna (MRNA-3.31%) and Pfizer (PFE 0.60%) may soon be sharing the coronavirus vaccine market with two more companies. Theres some good news about coadministration of flu and COVID-19 vaccines, said Dr. Fryhofer. But our cells recognize that this protein doesnt belong, and the immune system reacts by activating immune cells and producing antibodies. Always seek the individual advice of your health care provider with any questions you have regarding a medical condition. A two-dose series of Novavax protein subunit COVID vaccine is now recommended for unvaccinated individuals who are 12 or older for primary vaccination against COVID-19., But it is important to note that Novavax has to be used for both doses in the primary series, she said. The Motley Fool recommends Moderna Inc. There's some data suggesting that certain proteins in the heart look like spike proteinsbut it doesn't look that much like a spike protein, so why certain individuals have more of a reaction than others is still not clear, says Dr. Wilson. As vaccination rates stall nationwide,an additional vaccine like Novavax may seem unnecessary. How it works:Similar to the Pfizer vaccine, this is an mRNA vaccine that sends the bodys cells instructions for making a spike protein that will train the immune system to recognize it. The tangled history of mRNA vaccines. If you had COVID-19 recently, you might consider delaying your second primary dose or your booster by 3 months from when you started to experience symptoms or (if you had no symptoms) the date of your positive test result. Before that, it was the firstCOVID-19 vaccineto receive FDA Emergency Use Authorization (EUA) back in December 2020, after the company reported that its vaccine was highly effective at preventing symptomatic disease. doi:10.1056/nejmoa2107659. The incidence rates of adverse events such as anaphylaxis, myocarditis, pericarditis, and cerebral venous thrombosis blood clotting in the brain with the mRNA vaccines have stabilised, HSA said. In Novavax's case, I would strongly suggest you get both shots. It is simpler to make than some of the other vaccines and can be stored in a refrigerator, making it easier to distribute. All four were not serious and had reported experiencing rash, chest pain, dizziness, and vasculitis (blood vessel inflammation). We know people who have developed this rare condition are more likely to be male. The mRNA vaccine, as we've seen have been very fast. FDA warnings: The FDA added a warning labelon the mRNA vaccines regarding serious (but rare) cases of inflammation of the heart muscle (myocarditis) and of the outer lining of the heart (pericarditis) in adolescents and young adults, more often occurring after the second dose of an mRNA vaccine. A small rise in incidents of appendicitis two additional cases per 100,000 administered doses were observed occurring within 21 days after the primary vaccination series of the Pfizer vaccine, mainly in those aged 12 to 17. The Pfizer-BioNTech and Moderna COVID-19 vaccines use a newer mechanism in which messenger RNA is used to lead cells to create a protein on the virus surface that the immune system SAGE recommends the use of the Novavax (NVX-CoV2373) vaccine as 2 doses (0.5 ml) given intramuscularly. The inflammation, in most cases,

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