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Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. J Exp Med. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Hepatology. Mechanisms of fibrogenesis. 2018 12; 16(12):1974-1982.e7. 2017 01; 65(1):78-88. 2004 Dec; 127(6):1659. Data from arrays: an embarrassment of riches. La Jolla groups issue letter on city parks master plan. Fibrogenesis Tissue Repair. 2008 Feb; 233(2):109-22. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. 2000 Jan 15; 28(2):641-7. DNA Cell Biol. 2000; 32(1 Suppl):32-8. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. 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High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology. See more options in the Advanced Search tab. J Clin Invest. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Biochim Biophys Acta. J Clin Invest. Am J Physiol. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. Am J Hum Genet. 2020 Apr; 4(4):606-626. Black D, Bird MA, Hayden M, Schrum LW, Lange P, Samson C, Hatano E, Rippe RA. Gastroenterol Hepatol (N Y). Activation of Jun kinase is an early event in hepatic regeneration. Rippe RA, Umezawa A, Kimball JP, Breindl M. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. 1989 May; 8(4):279-85. 2012 Apr; 56(4):965-72. Nucleic Acids Res. Stimulation of collagen gene expression by ascorbic acid in cultured human fibroblasts. Studies with human cultured skin fibroblasts. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. 2001 Sep; 25(9):1360-7. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. 1991 Feb 01; 88(3):849-53. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Clin Gastroenterol Hepatol. Science. J Clin Invest. Mitogens and hepatocyte growth control in vivo and in vitro. 2020 12; 72(6):2182-2196. Hepatology. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. J Gastroenterol. 1998 Aug 10; 1366(1-2):177-96. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. 2003 Jan 10; 278(2):927-33. Nat Rev Gastroenterol Hepatol. Proc Natl Acad Sci U S A. J Hepatol. Circulation. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. 2011 Jan; 53(1):4-6. 1999 03; 276(3):G591-8. Ann Hepatol. 2022 Oct 28; 11(11). Cell Mol Gastroenterol Hepatol. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. 2008 Feb; 25(2):249-58. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. 2001 Aug; 21(3):437-51. 1999 Aug; 31(4):305-19. In Vitro Cell Dev Biol. Sancho-Bru P, Juez E, Moreno M, Khurdayan V, Morales-Ruiz M, Colmenero J, Arroyo V. 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Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. Nucleic Acids Res. 1994 Sep; 3(9):1695-7. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. 2000 Dec; 32(6):1255-64. J Clin Immunol. The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. 2012 Nov; 13(11):1072-82. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW. Hepatology. 2003 Jul 15; 76(1):28-37. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. 2017 02; 152(3):598-607.e2. Aliment Pharmacol Ther. Allergy. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. 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WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. Introducing PNAS Nexus. Immunosuppression, hepatitis B virus variants: Synergistic role in hepatic fibrogenesis. PLoS One. Mol Ther Nucleic Acids. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. FASEB J. Lindquist JN, Kauschke SG, Stefanovic B, Burchardt ER. Hepatology. Jiang C, Iwaisako K, Cong M, Diggle K, Hassanein T. Intestinal Virome in Patients With Alcoholic Hepatitis. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. NOX in liver fibrosis. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. J Biol Chem. Adv Second Messenger Phosphoprotein Res. Mol Metab. 2008 Apr 15; 5(3):338-42. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS. Cell Metab. 2016 Sep; 92(3):84-92. 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UCSD Profiles is managed by the UC San Diego Hepatology. 2007 Jun; 132(7):2601-4. J Biol Chem. 2003 Nov; 285(5):G949-58. Surgery. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. Gastroenterology. 1999; 8(3):151-63. Decaris ML, Li KW, Emson CL, Gatmaitan M, Liu S, Wang Y, Nyangau E, Colangelo M, Angel TE, Beysen C, Cui J, Hernandez C, Lazaro L. Magnetic Resonance Elastography vs Transient Elastography in Detection of Fibrosis and Noninvasive Measurement of Steatosis in Patients With Biopsy-Proven Nonalcoholic Fatty Liver Disease. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gut. 1998 09; 275(3):G387-92. Gastroenterology. 1989 Aug 11; 17(15):6055-64. 1996 Sep; 24(3):670-6. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. J Hepatol. 2015 Sep; 39 Suppl 1:S75-9. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. WebDavid Brenner. To a large degree, it was sparked by Dr. David Brenner, UC San Diegos vice chancellor for health sciences. 2015 Feb; 4(1):34-47. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Mazagova M, Wang L, Anfora AT, Wissmueller M, Lesley SA. 2021 09; 191(9):1564-1579. Carethers will report directly to the chancellor and is part of the leadership team. Transforming growth factor B and hepatic fibrosis: cause or effect? Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. Nat Rev Gastroenterol Hepatol. Lipopolysaccharide-binding protein modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation. Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models. Cellular differentiation causes a selective down-regulation of interleukin (IL)-1beta-mediated NF-kappaB activation and IL-8 gene expression in intestinal epithelial cells. Magness ST, Jijon H, Van Houten Fisher N, Sharpless NE. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. 2015 Nov-Dec; 49 Suppl 1:S69-73. 2017 10 10; 114(41):10808-10809. Dig Dis. J Immunol. Prog. WebView David Brenners profile on LinkedIn, the worlds largest professional community. Hepatology. J Biol Chem. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. 2013 Jun; 45(6):450-9. J Biol Chem. He did not respond to inewsource s interview request. 2001 Nov; 281(5):G1279-89. J Hepatobiliary Pancreat Sci. What's new in liver fibrosis? Mol Cell Biol. J Clin Invest. J Immunol. Hepatology. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. Hepatology. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. 2008 Nov; 48(5):1420-9. 2008 Jul; 48(1):322-35. Gastroenterology. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. 2003 Oct; 23(5):386-96. J Natl Cancer Inst. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. Am J Physiol Gastrointest Liver Physiol. 2003 May; 37(5):1043-55. 1994 Jul 29; 269(30):19203-6. DNA. Gastroenterology. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. Gastroenterology. 2022 08; 42(3):233-249. Front Physiol. 2005 Apr; 115(4):849-59. New Approaches for Studying Alcoholic Liver Disease. Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. 2006 Apr; 12(4):550-9. Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to J Gastroenterol Hepatol. 2017 Jun 16; 7:314-323. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Hepatology. 2012 Nov; 67(11):1357-64. Altman Clinical and Translational Research Institute (ACTRI). 2015 Feb; 21(2):159-65. Arch Biochem Biophys. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. Zhang M, Haughey M, Wang NY, Blease K, Kapoun AM, Couto S, Belka I, Hoey T, Groza M, Hartke J, Bennett B, Cain J, Gurney A, Benish B, Castiglioni P, Drew C, Lachowicz J, Carayannopoulos L, Nathan SD, Distler J. Vuori will Proc Natl Acad Sci U S A. Gastroenterology. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. 2019 Apr 07; 20(7). NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. Cell therapy attenuates deleterious ventricular remodeling and improves cardiac performance after myocardial infarction. Am J Physiol Gastrointest Liver Physiol. 2000 Nov 01; 28(21):4306-16. Gastroenterology. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Hepatology. 2005 Jul 29; 280(30):27879-87. Liver: DNA methylation controls liver fibrogenesis. 2013; 8(2):e56116. Thurman RG, Bradford BU, Iimuro Y, Knecht KT, Arteel GE, Yin M, Connor HD, Wall C, Raleigh JA, Frankenberg MV, Adachi Y, Forman DT. 2003 Mar; 37(3):493-503. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Brain Commun. J Cell Biol. Cell Metab. 2001 Jan; 33(1):81-90. 1988 Sep-Oct; 8(5):1040-5. Senderek J, Lassuthova P, Kabzinska D, Abreu L, Baets J, Beetz C, Braathen GJ. Scelzo A, Di Somma S, Antonini P, Montross LP. Transient induction of c-jun during hepatic regeneration. 2021; 16(12):e0260721. Hum Gene Ther. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. Cell Death Differ. Immortal activated human hepatic stellate cells generated by ectopic telomerase expression. Role of toll-like receptors and their downstream molecules in the development of nonalcoholic Fatty liver disease. 2010 Oct; 8(10):891-8, 898.e1-2. 2000 Jul; 33(1):49-58. Analysis of the collagen alpha 1(I) promoter. Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS. Genomics of liver fibrosis and cirrhosis. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. 2007 Aug; 22(8):1256-64. 1996 Nov; 271(5 Pt 1):G780-90. Proc Natl Acad Sci U S A. 1996 Feb; 23(2):379-80. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. Hellerbrand C, Stefanovic B, Giordano F, Burchardt ER. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. 2001 Apr; 120(5):1251-62. 2020 05; 72(5):946-959. NEK1 mutations in familial amyotrophic lateral sclerosis. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. He will assume his new role effective September 14. 2020 02 13; 5(3). Derived automatically from this person's publications. 1998 Nov; 18(11):6353-64. 2020; 4(5):561-580. Am J Respir Cell Mol Biol. CCR1 and CCR5 promote hepatic fibrosis in mice. Gastroenterology. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. 1990 Feb; 10(1):75-83. Enomoto N, Ikejima K, Yamashina S, Enomoto A, Nishiura T, Nishimura T. Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. 1999 09; 277(3):G671-7. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Mol Pharmacol. 2012 Jul; 36(1):22-9. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S. Hepatocarcinoma cells stimulate the growth, migration and expression of pro-angiogenic genes in human hepatic stellate cells. 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