The Adviser has complete and unlimited discretion and authority with respect to the investment and voting power of the securities held by the Funds. Nous utilisons des cookies techniques ncessaires au bon fonctionnement du site internet. Co-Founder and Managing Partner, Baker Brothers Investments. Baker Brothers, a biotech investment firm, was founded by Julian & Felix Baker in 2000. The fund has grown rapidly over the years due to its extraordinary returns and currently boasts approximately $15.2 billion of assets under management (AUM). Farah Champsi MBA '85. For more information, please see the SECs Web Site Privacy and Security Policy. (i)Severability. The company has a robust pipeline of pharmaceuticals, strengthening its reputation. for so long as they remain in force, the Voting Agreement (as defined in the Purchase Agreement) and that certain letter agreement, dated as of January15, 2021, by and among the Company and the Investor, constitutes the full and entire Investors that are familiar with biotech companies are likely to find some hidden gems amongst their holdings. Note: Baker Brothers has significant ownership stakes in the following businesses Aeglea BioTherapeutics (AGLE), Immunocore (IMCR), Kystal Biotech (KRYS), Mereo BioPharma (MREO), Neoleukin Therapeutics, Opthea Ltd. (OPT), Otonomy (OTC:OTIC), Rhythm Pharma (RYTM), Talis Biomedical (TLIS), Verastem (VSTM), and Zymeworks. Shares started trading at ~$18 and currently goes for $27.21. Note: Baker Brothers controls ~29% of the business. IN WITNESS WHEREOF, each of the parties hereto has executed this Amended and Restated I/we have a beneficial long position in the shares of ACAD, BMRN, INCY either through stock ownership, options, or other derivatives. Baker Brothers, a biotech investment firm, was founded by Julian & Felix Baker in 2000. Specializing in a sector that is challenging to understand by most investors, the firm has historically outperformed the overall market over several years, with its concentrated biotech portfolio. Although there are ~120 positions in the 13F portfolio, the holdings are concentrated among a few large stakes. AMENDED AND RESTATED NOMINATING AGREEMENT. The funds philosophy stands in holding its investments ordinarily for three years, though its higher-conviction investments can be seen held for longer. Phone: 212-339-5600. Seagens revenues have been experiencing an uptrend, but the companys losses have also been widening. Incyte Corporation focuses on the discovery, development, and commercialization of various therapeutics. Most recently, BioMarine got a positive CHMP opinion in Europe for ValRox for the treatment of Hemophilia type A. BioMarine has had a place in Baker Bros portfolio since Q2 2012. Ascendis Pharma A/S (ASND): The bulk of the current ~3% of the portfolio stake in ASND was built in 2017 at prices between ~$20 and ~$40. Over the years, the firm had a number of home runs as the invested firms got acquired at huge premiums. Note that this policy may change as the SEC manages SEC.gov to ensure that the website performs efficiently and remains available to all users. This is compared to ~32M shares in the 13F report. Reference ID: 0.bfed655f.1677703966.7fc99eb. All text and design is copyright 2020 WhaleWisdom.com. The reporting persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the . This Agreement, the Bylaws and BioMarin Pharmaceutical (BMRN): A small stake in BMRN was first purchased in 2006 but was eliminated the following year at higher prices. Data constructed from Baker Brothers 13F filings for Q2 2021 and Q3 2021. Last major activity was in Q4 2018 when there was a ~40% stake increase at prices between ~$14 and ~$22. Nonetheless, BeiGene produces miniature revenues against its $18.7 billion market cap, indicating that investors are betting heavily on the companys long-term prospects. If a user or application submits more than 10 requests per second, further requests from the IP address(es) may be limited for a brief period. This cookie is set by GDPR Cookie Consent plugin. Lists Featuring This Company Early Stage Venture Investors (Top 10K) 10,000 Number of Organizations $63B Total Funding Amount 1,945 Number of Investors Track Private New York Companies (Top 10K) Note: Baker Brothers controls ~26% of the business. Necessary cookies are absolutely essential for the website to function properly. Unauthorized attempts to upload information and/or change information on any portion of this site are strictly prohibited and are subject to prosecution under the Computer Fraud and Abuse Act of 1986 and the National Information Infrastructure Protection Act of 1996 (see Title 18 U.S.C. Q1 2016 saw another ~20% stake increase at prices between ~$65 and ~$100. Companys shares are listed, the Bylaws or any policy, or guidelines previously approved by the Board of Directors, provided that a direct or indirect purpose of any such policy or guideline is not to obstruct the Investors right to under clause (c)or (d); (c) by prepaid certified or registered mail, return receipt requested;or (d)by prepaid reputable overnight delivery service. NEW YORK, NY The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features. Note: Baker Brothers controls ~10% of BioCryst Pharmaceuticals. Baker Brothers Life Sciences, L.P. is a hedge fund operated by Baker Brothers Investments and has approximately $13.9 billion in assets. These investors may include private investors, venture capital firms, or other investment vehicles. But opting out of some of these cookies may have an effect on your browsing experience. Nominating Agreement as of the date first above written. Julian & Felix Baker also separately own ~550K additional shares. Baker Bros. Advisors LP 860 Washington Street, 3rdFloor New York, NY 10014 (212) 339-5690 (Name, address and telephone number of person authorized to receive notices and communications) January 12, 2023 (Date of event which requires filing of this statement) If the filing person has previously filed a statement on Schedule This quarter also saw a minor ~4% trimming. Council Members. (f)Purchase 13F filing from Baker Brothers Life Sciences LP, enter your Notices must be given: (a)by personal delivery, with receipt acknowledged; (b)by email followed by hard copy delivered by the methods (c)Subject at all times to Section3(n) below and the other limitations set forth in this The position has remained almost steady since. EPS over the medium-term is expected to grow by around 30% since Incyte is an industry leader, having essentially monopolized its areas of treatment. Click to reveal Please disable your ad-blocker and refresh. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Agreement. The parties agree to use their best efforts and act in good faith in carrying out Recent M&A winners include Pharmacyclics (acquired by AbbVie), Synageva (acquired by Alexion), Salix (acquired by Valeant), and Alexion (acquired by AstraZeneca). (d)Successors and Assigns. The stock currently trades at $3.46. These cookies ensure basic functionalities and security features of the website, anonymously. Although there are ~120 positions in the 13F portfolio, the holdings are concentrated among a few large stakes. We also use third-party cookies that help us analyze and understand how you use this website. It is based on Baker Brothers regulatory 13F Form filed on 11/15/2021. Current guidelines limit users to a total of no more than 10 requests per second, regardless of the number of machines used to submit requests. While the companys revenue growth has seemingly stagnated over the past couple of years, it appears that the companys development pipeline remains rather strong. (a)Subject at all times to Sections 2(b) and 3(n) below, during the period beginning immediately following the Note: We do not offer technical support for developing or debugging scripted downloading processes. Baker Bros owns around 25.5% of the company, the stock occupies around 38.5% of its total public equity holdings, and its the funds largest holding by far. value remained steady this quarter at $22.77B. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc. The stock currently trades at $71.81. All rights reserved. It is the funds second-largest holding, occupying 14.9% of its total portfolio. PitchBook helps you see a funds investments based on target industry, year and deal typeso you can quickly understand its strategy at a glance. Q4 2018 saw a ~55% selling at prices between ~$9.50 and ~$15. Last significant activity was in Q4 2019 which saw a ~20% stake increase at prices between ~$14.50 and ~$76. I am not receiving compensation for it (other than from Seeking Alpha). Analytical cookies are used to understand how visitors interact with the website. Last major activity was a ~60% stake increase in 2017 at prices between ~$80 and ~$95. This website uses cookies to improve your experience while you navigate through the website. Except as otherwise provided herein, the provisions hereof shall inure to the substantially the same time and in the same manner as provided to such directors; provided, however, that such Observer shall agree to hold in confidence all information so provided; and provided, further, that the Company The parties The position was rebuilt in Q3 2019 at prices between ~$18.50 and ~$27. Note: Baker Brothers controls ~5.5% of Amarin Corp. Seagen Inc. (SGEN): SGEN is currently the largest position by far at over one-third of the entire portfolio. Mr. Goller began his career as an investment banker with Merrill Lynch and Co. from 1997 to 1999. The position was built to ~20.5M shares in the 2004-2011 timeframe at prices between low-single-digits and low-20s. Broker-Dealer(s): Goldman, Sachs & Co., . Kath Lavidge '74, P '09 - Chair. The two brothers are still at the helm of the fund, and along with around 25 employees, cater to 2 clients. Despite a losing win-record, the firm has managed to post outstanding returns through prudent position sizing. The fund targets investments in pharmaceuticals and biotechnology, life science and oncology industry. The parties also agree, without further consideration, to execute such further instruments and to take such further actions as may be necessary or desirable to carry out the purposes and intent of this We are EVERSANA. removed or otherwise fails to become or ceases to be a director for any reason, the Company shall cause the vacancy to be filled by the election or appointment of another Investor Designee nominated by the Investor as soon as reasonably practicable laws of the State of Delaware, without giving effect to its principles of conflicts of laws. The filing was for a pooled investment fund: other investment fund The notice included securities offered of Pooled Investment Fund Interests. This website uses cookies to improve your experience. The funds strategy includes utilizing a fundamentally-driven way of investing to come up with its investment decisions, also known as bottom-up investing. Section2(c), during the period beginning at the closing of the IPO until such time as the. of such counsel, that such person would not be qualified to serve as a director of the Company under any applicable law (including requirements of fiduciary duties under applicable law), rule or regulation, rule of the stock exchange on which the Baker Bros. Advisors (GP) LLC (the "Adviser GP") is the Adviser's sole general partner. The fund is located in New York, New York and will invest in United States. Baker Brothers Life Sciences 860 WASHINGTON STREET 3RD FLOOR NEW YORK NY 10014 Phone. Investor and its Affiliates, collectively, no longer beneficially own the Required Shares, the Company shall invite a designee of the Investor (the Observer) to attend all The company was incorporated in 1991 and is headquartered in Wilmington, Delaware. 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